Gateway Biome is developing an early-life microbiome trajectory as an indicator for early intervention.

Gateway Biome is developing an early-life microbiome trajectory as an indicator for early intervention. 

Gateway Biome (GB) is developing an innovative health screening tool based on functional (metabolomic) measures that assesses the health of the early life gut microbiome (ELM) and its developmental trajectory. Mounting research suggests that the gut microbiome, the massive collection of bacteria and microbes in our digestive tract, plays a significant role in our physical and mental health conditions.

Perturbations of the ELM can increase the risk for lifelong diseases such as complex immune disorders, metabolic diseases, improper skeletal development, and cognitive and behavioral disorders. 

Yet, there are no clinical tools for assessing if the health and developmental trajectory of the ELM is proceeding normally or is disturbed.   

Gateway Biome is developing a health screening tool for assessing the gut microbiome of older adults to identify those people most at risk for declining health. 

Mounting research suggests that the gut microbiome may play roles in many age-related conditions, such as cognitive decline, loss of immune tolerance, increased incidence of a number of diseases, and increasing frailty. But, little is known about when aging-related microbiome changes begin and whether these changes are causative or correlative with declining health. 

Given the increasing older population in the US, there is a significant need to address these questions and develop a means of determining which older adults would benefit from an intervention to change their trajectory toward frailty. 

To address these issues, Gateway Biome is developing a novel health screening tool for identifying those seniors most at risk for declining health and quality of life.